Advantages

‐ Chemical-Free and Non-Invasive Simplicity: Selective depletion of primordial germ cells (PGCs) inside fertilized eggs solely through genetic crossings.
- Enhanced Embryo Survival and Hatchability: Complete elimination of physical bleeding procedures and chemical toxicity risks.
- Superior Germline Transmission: Maximized colonizing efficiency of donor cells by eliminating competition with endogenous PGCs.
- Drastic Cost and Time Reduction: Significant decrease in the required screening period and number of progeny chicks.

Current Stage and Key Data

Proof-of-concept (PoC) in vivo completed using Super Recipient Embryos.
- Effective endogenous PGC removal without external drug administration.

Partnaring Model

Patent licensing, joint research for application development.
- Potential partners: Veterinary/biopharmaceutical manufacturers, CRO/CDMOs for transgenic animals, and poultry breeding companies.

Background and Technology

Avian platform technology using primordial germ cells (PGCs) is gaining attention for recombinant protein production and genetic resource preservation. However, conventional methods suffer from severe competition between transplanted and host endogenous PGCs, requiring invasive physical bleeding or chemical treatments that cause low hatchability and poor transmission efficiency. This technology establishes Super Recipient Embryos through purely genetic breeding to selectively deplete endogenous PGCs, markedly improving production efficiency without embryonic damage.

Principal Investigator

Ken-ichi Nishijima (Graduate School of Bioagricultural Science, Nagoya University, TNHERS)

Patents and Publications

- Patent pending