Advantage and Core Benefit

- Facilitates induction from dental pulp cells to odontoblasts in pulp therapy.
- Potential for differentiated cells to contribute to a new dentin-regenerating pulp capping material in the future.

Background and Technology

In direct pulp capping for caries treatment, which aims to protect the dental pulp, repair dentin is induced on the exposed pulp surface. Caries that have reached the pulp without removing the pulp are repaired by covering the pulp surface with repaired dentin. However, despite the dental pulp being a reservoir of stem cells, methods for inducing differentiation of odontoblasts, which form dentin from the dental pulp, have yet to be established, and efficient methods to promote dentinogenesis have yet to be obtained. Therefore, researchers have found that by controlling the oxidation reaction using MA-T (Matching Transformation System | On-demand generated chlorine dioxide aqueous solution) and using differentiation-inducing agents composed of ammonium salts, dental pulp cells can be induced to differentiate into odontoblasts. This discovery may lead to developing superior medicaments for dentin regeneration and pulp capping materials.

Data

Expectations

We seek companies interested in developing dentin-regenerating pulp capping materials while advancing collaborative research based on this technology. Meetings with Dr. Yamashiro, the inventor, are also possible. Please do not hesitate to contact us if you are interested.

Patents and Publications

Publications
Sec. Stem Cell Research Volume 11 – 2023 (doi.org/10.3389/fcell.2023.1271455)

Patents
application in progress

Researcher

Takashi Yamashiro (Professor, Graduate School of Dentistry, The University of Osaka)
Project No. DD-04073