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Therapeutic-drug

GBF1-targeted broad-spectrum antiviral nucleic acid therapeutics

A novel concept that targets GBF1, a host factor shared by diverse RNA viruses, to enable broad-spec…

A candidate compound for promoting bone formation

Bone volume was increased through the enhanced bone formation in vivo, and the mechanism of action i…

Tolvaptan Silicon Analogues with Markedly Enhanced Brain Penetration

Novel silicon-containing analogues of tolvaptan, created by replacing a ring carbon with silicon (ca…

Tumor Immune Activation via Reprogramming of Tumor-Associated Macropha...

Arginine nanomicelles for high-dose delivery to the TME; they synergize with PD-1 antibodies to accu…

Novel Therapeutic for Triazole-Resistant Pulmonary Aspergillosis

A combination therapy of an existing triazole and low-dose Luliconazole restores drug sensitivity in…

Novel FAPα-Targeted Radiopharmaceutical

A therapeutic agent targeting refractory solid tumors such as pancreatic cancer and triple-negative …

LNP-DDS for Pancreatic Islet β-Cells

Achieving highly efficient drug delivery to pancreatic islets through phospholipid selection and par…

Novel Therapeutic Target to Overcome Resistance to Multi-Kinase Inhibi...

Targeting TKI-Induced GTP Metabolic Dependency: Enhancing Lenvatinib Sensitivity via IMPDH Inhibitio…

CAF-targeted in vivo CAR-T Therapy

Effective CAF elimination by targeting the FAP protein highly expressed on CAF surfaces via in vivo …

Therapeutics for respiratory infections targeting ALKAL1 signaling

Inhibition of ALKAL1 (ALK and LTK ligand 1)–mediated signaling attenuates severe respiratory symptom…